Human chromosome 7 carries a putative tumor suppressor gene(s) involved in choriocarcinoma
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منابع مشابه
Promoter Methylation of Four Tumor Suppressor Genes in Human Papillary Thyroid Carcinoma
Background & Objective: Papillary thyroid cancer (PTC) is considered to be the most common type of thyroid malignancies. Epigenetic alteration, in which the chromatin conformation and gene expression change without changing the sequence of DNA, can occur in some tumor suppressor genes and oncogenes. Methylation is the most common type of epigenetic alterations that can be an ex...
متن کاملDNA methylation of tumor suppressor genes in hepatocellular carcinoma
The basic unit of chromatin is a nucleosome included an octamer of the four core histones and 147 base pairs of DNA. Posttranslational histones modifications affect chromatin structure resulting in gene expression changes. CpG islands hypermethylation within the gene promoter regions and the deacetylation of histone proteins are the most common epigenetic modifications. The aberrant patterns of...
متن کاملcomputational survey of fhit, a putative human tumor suppressor, truncates structure
background: fragile histidine triad protein (fhit), as a known tumor suppressor protein, has been proposed to play crucial role in inhibiting p53 degradation by mdm2. studies have confirmed fhit interaction with p53 or mdm2, although functional interacting domains of fhit with mdm2 and/or p53 are not completely defined. thus, through determining the significant structural interacting domains of...
متن کامل[Tumor suppressor genes in human urological malignancies].
はじめに 悪性腫瘍は今や日本人の死因の第1位 を占める疾患 であり, 過去4半 世紀の間に多くの進歩は見られたも のの, 現代でもその診断や治療は困難であることが多 い. 近年の分子生物学的な手法による遺伝子解析によ り, 癌の発生, 進展は特定の遺伝子群に起こるDNAの 損傷の蓄積 と考えられている. 化学発癌の考え方では 自然環境中に存在する発癌物質や, 自然界の放射線や, 紫外線によりこれらの遺伝子上のDNAの 損傷(=遺 伝子異常)が 引き起こされると考えられる. 癌化しつ つある細胞はしばしばこれらのDNAの 傷を修復する 機能を失っており, これらの異常が癌遺伝子や癌抑制 遺伝子のような特定の遺伝子群におこるがDNAの 損 傷が固定される結果, ある場合は直接, 細胞の増殖や 脱分化が進行し, (細胞の増殖を自動車にたとえれば自 動車のアクセルをかけることになり)そ の結...
متن کاملThe candidate tumor suppressor gene, RASSF1A, from human chromosome 3p21.3 is involved in kidney tumorigenesis.
Clear cell-type renal cell carcinomas (clear RCC) are characterized almost universally by loss of heterozygosity on chromosome 3p, which usually involves any combination of three regions: 3p25-p26 (harboring the VHL gene), 3p12-p14.2 (containing the FHIT gene), and 3p21-p22, implying inactivation of the resident tumor-suppressor genes (TSGs). For the 3p21-p22 region, the affected TSGs remain, a...
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ژورنال
عنوان ژورنال: Oncogene
سال: 1997
ISSN: 0950-9232,1476-5594
DOI: 10.1038/sj.onc.1201461